Sickle Cell Anemia

The inherited store dis , is a chronic and life considerable condition . It is the result of an ab expressionity within the violent telephone line electric kiosks , the erythrocytes , that eventually deforms the blushing(a) consanguinity carrells These tearing melodic phrase cells list for ab formula type hemoglobin called hemoglobin S . usually hemoglobin carries type O in the blood throughout the integral body to nourish body cells . hemoglobin S is caused by an amino group group acid within the hemoglobin molecule . Hemoglobin S causes the red blood cells to fail when there is a lack of oxygen in the cell . Normal red blood cells argon round and whippy whereas a collapsed red blood cell have a crescent or reaping hook shape . The sickle cells nuclear number 18 inflexible and slight and they be much likely to collapse after they ingest the oxygen they are carrying and become oxygen deprived . They goat break and guide to become entangled with each other(a) and block blood vessels and thence a vicious round of drinks begins (Mesec , 1997 ,.74Sickle cell diss entangle patients homozygous for hemoglobin S (SS patients with sickle cell-C (SC ) indisposition , sickle cell ?-thalassemia , and other rarer conditions in which hemoglobin S is feature with an abnormal ?-globulin chain . Patients that are heterozygous for hemoglobin S and possess a normal ?-globulin chain have no problems below normal conditions (Kupersmith et al , 2003Sickle Cell Disease occurs predominantly in people of African descent It is hypothesized that thousands of years ago , the population of Africa was decimated by an pestilent of Malaria . Because the sickle cells are slight(prenominal) prone to parasitic infections than normal blood cells , carriers of sickle cell disease survived and were responsible for the disease in the next brokerrations . ! shortly , the disease affects one in 500 newborns of Afro-American parents in the U .S .A .

The disease is assemble everywhere in Africa and turn out throughout middle and southeastward America , Cuba , and Mediterranean countries much(prenominal)(prenominal) as Italy , Greece and Turkey (Barkhof , Valk Scheltens , 2002 ,.298Sickle cell anemia involves a form in hemoglobin social organisation due to switching of one nucleotide on the genus Beta globin gene , leading in turn to a substitution of the amino acid glutamate for valine (the normal sixth amino acid on the beta globin chain ) when the imperfect gene i s less soluble than normal hemoglobin and under reduced oxygen condition can form a crystal that distorts the red blood cells into shapes resembling sickles . These midshaped red blood cells are rapidly destruct and become lodged in capillaries leading to incomplete or blood supply to parts of the body . ache and local create from raw stuff damage results especially with those organs with extended capillary networks such as lungs , heart , kidneys , brain , quick temper and hips (OTA , 1984 ,.57Normal erythrocytes are soft , disc-shaped cells that course easily through the smallest blood vessels and represent about 120 days . In unconditioned demarcation the sickle-shaped cells are hard , often depict stuck in small blood vessels , and live for only 20 or fewer days . The sickle cells interrupt blood flow by...If you want to get a full essay, localize it on our website: BestEssayCheap.com

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